Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25

The recently discovered mitochondrial calcium uniporter (MCU) promotes Ca(2+) accumulation into the mitochondrial matrix [1, 2]. We identified in silico miR-25 as a cancer-related MCU-targeting microRNA family and demonstrate that its overexpression in HeLa cells drastically reduces MCU levels and m...

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Auteurs principaux: Marchi, Saverio, Lupini, Laura, Patergnani, Simone, Rimessi, Alessandro, Missiroli, Sonia, Bonora, Massimo, Bononi, Angela, Corrà, Fabio, Giorgi, Carlotta, De Marchi, Elena, Poletti, Federica, Gafà, Roberta, Lanza, Giovanni, Negrini, Massimo, Rizzuto, Rosario, Pinton, Paolo
Format: Artigo
Langue:Inglês
Publié: Cell Press 2013
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540261/
https://ncbi.nlm.nih.gov/pubmed/23246404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.11.026
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