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Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy
The autophagy factor ATG12~ATG5 conjugate exhibits E3 ligase-like activity by which the lipidation of members of the LC3 family is facilitated. The crystal structure of the human ATG12~ATG5 conjugate bound to the amino-terminal region of ATG16L1, the factor that recruits the conjugate to autophagoso...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3540207/ https://ncbi.nlm.nih.gov/pubmed/23202584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2431 |
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