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Quantitative Imaging of Mitochondrial and Cytosolic Free Zinc Levels in an in vitro Model of Ischemia/Reperfusion

The role of zinc ion in cytotoxicity following ischemic stroke, prolonged status epilepticus, and traumatic brain injury remains controversial, but likely is the result of mitochondrial dysfunction. We describe an excitation ratiometric fluorescence biosensor based on human carbonic anhydrase II var...

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Detalhes bibliográficos
Main Authors: McCranor, Bryan J., Bozym, Rebecca A., Vitolo, Michele I., Fierke, Carol A., Bambrick, Linda, Polster, Brian M., Fiskum, Gary, Thompson, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539817/
https://ncbi.nlm.nih.gov/pubmed/22430627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10863-012-9427-2
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