Down-Modulation of Expression, or Dephosphorylation, of IG20/MADD in Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Resistant Thyroid Cancer Cells Makes Them Susceptible to Treatment with This Ligand

BACKGROUND: The IG20/MADD gene is overexpressed in thyroid cancer tissues and cell lines, and can contribute to tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) resistance. The ability of the MADD protein to resist TRAIL-induced apoptosis is dependent upon its phosphorylation by Akt....

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Bibliographic Details
Main Authors: Li, Liang-Cheng, Jayarama, Shankara, Pilli, Tania, Qian, Lixia, Pacini, Furio, Prabhakar, Bellur S.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2013
Subjects:
Thyroid Cancer and Nodules
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539253/
https://ncbi.nlm.nih.gov/pubmed/22998497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2012.0155
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