Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex

RATIONALE: Alteration of dopamine neurotransmission in the prefrontal cortex, especially hypofunction of dopamine D1 receptors, contributes to psychotic symptoms and cognitive deficit in schizophrenia. D1 receptors signal through the cAMP/PKA second messenger cascade, which is modulated by phosphodi...

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Hauptverfasser: Kuroiwa, Mahomi, Snyder, Gretchen L., Shuto, Takahide, Fukuda, Atsuo, Yanagawa, Yuchio, Benavides, David R., Nairn, Angus C., Bibb, James A., Greengard, Paul, Nishi, Akinori
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539205/
https://ncbi.nlm.nih.gov/pubmed/21833500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-011-2436-8
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