Neutralization of influenza A viruses by insertion of a single antibody loop into the receptor binding site

Immune recognition of protein antigens relies upon the combined interaction of multiple antibody loops, which provides a fairly large footprint and constrains the size and shape of protein surfaces that can be targeted. Single protein loops can mediate extremely high affinity binding, but it is uncl...

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Detalhes bibliográficos
Main Authors: Ekiert, Damian C., Kashyap, Arun K., Steel, John, Rubrum, Adam, Bhabha, Gira, Khayat, Reza, Lee, Jeong Hyun, Dillon, Michael A., O’Neil, Ryann E., Faynboym, Aleksandr M., Horowitz, Michael, Horowitz, Lawrence, Ward, Andrew B., Palese, Peter, Webby, Richard, Lerner, Richard A., Bhatt, Ramesh R., Wilson, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538848/
https://ncbi.nlm.nih.gov/pubmed/22982990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11414
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