Ca(2+) Release in Muscle Fibers Expressing R4892W and G4896V Type 1 Ryanodine Receptor Disease Mutants

The large and rapidly increasing number of potentially pathological mutants in the type 1 ryanodine receptor (RyR1) prompts the need to characterize their effects on voltage-activated sarcoplasmic reticulum (SR) Ca(2+) release in skeletal muscle. Here we evaluated the function of the R4892W and G489...

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Detalhes bibliográficos
Main Authors: Lefebvre, Romain, Legrand, Claude, Groom, Linda, Dirksen, Robert T., Jacquemond, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538700/
https://ncbi.nlm.nih.gov/pubmed/23308296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054042
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