LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein

BACKGROUND: Human Immunodeficiency Virus-1 (HIV-1) associated neurocognitive disorders (HANDs) are accompanied by significant morbidity, which persists despite the use of combined antiretroviral therapy (cART). While activated microglia play a role in pathogenesis, changes in their immune effector f...

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Main Authors: Marker, Daniel F, Puccini, Jenna M, Mockus, Taryn E, Barbieri, Justin, Lu, Shao-Ming, Gelbard, Harris A
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538654/
https://ncbi.nlm.nih.gov/pubmed/23190742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-261
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