Cetuximab-mediated Tumor Regression Depends on Innate and Adaptive Immune Responses

Epidermal growth factor receptor (EGFR) over-signaling leads to more aggressive tumor growth. The antitumor effect of Cetuximab, an anti-EGFR antibody, depends on oncogenic-signal blockade leading to tumor cell apoptosis and antibody dependent cell-mediated cytotoxicity (ADCC). However, whether adap...

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Bibliografiske detaljer
Main Authors: Yang, Xuanming, Zhang, Xunmin, Mortenson, Eric D, Radkevich-Brown, Olga, Wang, Yang, Fu, Yang-Xin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538305/
https://ncbi.nlm.nih.gov/pubmed/22990672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.184
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