Inhibition of the Interaction Between NS3 Protease and HCV IRES With a Small Peptide: A Novel Therapeutic Strategy

Recently, we have demonstrated that the protease domain of NS3 alone can bind specifically to hepatitis C virus (HCV) internal ribosome entry site (IRES) near the initiator AUG, dislodges human La protein and inhibits translation in favor of viral RNA replication. Here, by using a computational appr...

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Detalhes bibliográficos
Main Authors: Ray, Upasana, Roy, Chaitrali L, Kumar, Anuj, Mani, Prashant, Joseph, Agnel P, Sudha, G, Sarkar, Debi P, Srinivasan, N, Das, Saumitra
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538298/
https://ncbi.nlm.nih.gov/pubmed/22910295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.151
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