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Anti-folate combination therapies and their effect on the development of drug resistance in Plasmodium vivax

Can we predict the rise and spread of resistance to multi-drug therapy in a more predictable manner? We raise this question after analyzing over 500 Plasmodium vivax isolates collected from different, geographically isolated regions of China for sequence variation in and around the dhfr and dhps gen...

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Autori principali: Ding, Shuai, Ye, Run, Zhang, Dongmei, Sun, Xiaodong, Zhou, Hongning, McCutchan, Thomas F., Pan, Weiqing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538286/
https://ncbi.nlm.nih.gov/pubmed/23301149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01008
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