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A Pictet-Spengler ligation for protein chemical modification
Aldehyde- and ketone-functionalized proteins are appealing substrates for the development of chemically modified biotherapeutics and protein-based materials. Their reactive carbonyl groups are typically conjugated with α-effect nucleophiles, such as substituted hydrazines and alkoxyamines, to genera...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3538270/ https://ncbi.nlm.nih.gov/pubmed/23237853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213186110 |
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