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Proteasome inhibition rescues clinically significant unstable variants of the mismatch repair protein Msh2
MSH2 is required for DNA mismatch repair recognition in eukaryotes. Deleterious mutations in human MSH2 account for approximately half of the alleles associated with a common hereditary cancer syndrome. Previously, we characterized clinically identified MSH2 missense mutations, using yeast as a mode...
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| Main Authors: | , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
National Academy of Sciences
2013
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3538226/ https://ncbi.nlm.nih.gov/pubmed/23248292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215510110 |
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