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Proteasome inhibition rescues clinically significant unstable variants of the mismatch repair protein Msh2

MSH2 is required for DNA mismatch repair recognition in eukaryotes. Deleterious mutations in human MSH2 account for approximately half of the alleles associated with a common hereditary cancer syndrome. Previously, we characterized clinically identified MSH2 missense mutations, using yeast as a mode...

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Bibliografiset tiedot
Päätekijät: Arlow, Tim, Scott, Kristan, Wagenseller, Aubrey, Gammie, Alison
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538226/
https://ncbi.nlm.nih.gov/pubmed/23248292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215510110
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