Resistance of glioblastoma initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β (TGFβ)

The poor prognosis of glioblastoma (GBM) routinely treated with ionizing radiation (IR) has been attributed to the relative radioresistance of glioma initiating cells (GIC). Other studies suggest that GIC are sensitive but the response is mediated by undefined factors in the microenvironment. GBM pr...

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Main Authors: Hardee, Matthew E., Marciscano, Ariel E., Medina-Ramirez, Christina M., Zagzag, David, Narayana, Ashwatha, Lonning, Scott M., Barcellos-Hoff, Mary Helen
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538149/
https://ncbi.nlm.nih.gov/pubmed/22693253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-0546
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