Resistance of glioblastoma initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β (TGFβ)

The poor prognosis of glioblastoma (GBM) routinely treated with ionizing radiation (IR) has been attributed to the relative radioresistance of glioma initiating cells (GIC). Other studies suggest that GIC are sensitive but the response is mediated by undefined factors in the microenvironment. GBM pr...

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Detalhes bibliográficos
Main Authors: Hardee, Matthew E., Marciscano, Ariel E., Medina-Ramirez, Christina M., Zagzag, David, Narayana, Ashwatha, Lonning, Scott M., Barcellos-Hoff, Mary Helen
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538149/
https://ncbi.nlm.nih.gov/pubmed/22693253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-0546
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