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Critical role of intracellular osteopontin in anti-fungal innate immune responses

We found that absence of osteopontin (OPN) in immunocompromised Rag2(−/−) mice, which lack T and B cells, made the mice extremely susceptible to an opportunistic fungus Pneumocystis, although immunocompetent OPN-deficient mice could clear Pneumocystis as well as wild-type mice. OPN has been studied...

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Dettagli Bibliografici
Autori principali: Inoue, Makoto, Moriwaki, Yasuhiro, Arikawa, Tomohiro, Chen, Yu-Hsun, Oh, Young Joo, Oliver, Timothy, Shinohara, Mari L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538145/
https://ncbi.nlm.nih.gov/pubmed/21135164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002735
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