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Critical role of intracellular osteopontin in anti-fungal innate immune responses
We found that absence of osteopontin (OPN) in immunocompromised Rag2(−/−) mice, which lack T and B cells, made the mice extremely susceptible to an opportunistic fungus Pneumocystis, although immunocompetent OPN-deficient mice could clear Pneumocystis as well as wild-type mice. OPN has been studied...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3538145/ https://ncbi.nlm.nih.gov/pubmed/21135164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002735 |
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