Toll-Like Receptor 4 Signaling Augments Transforming Growth Factor-β Responses: A Novel Mechanism for Maintaining and Amplifying Fibrosis in Scleroderma

Because recent studies implicate Toll-like receptors (TLRs) in the pathogenesis of fibrosis, we sought to investigate the in vitro and in vivo role and mechanism of TLR4-mediated fibroblast responses in fibrogenesis. We found that TLR4 was constitutively expressed, and accumulation of endogenous TLR...

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Detalhes bibliográficos
Main Authors: Bhattacharyya, Swati, Kelley, Kathleen, Melichian, Denisa S., Tamaki, Zenshiro, Fang, Feng, Su, Yunyun, Feng, Gilbert, Pope, Richard M., Budinger, G.R. Scott, Mutlu, Gökhan M., Lafyatis, Robert, Radstake, Timothy, Feghali-Bostwick, Carol, Varga, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2013
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538029/
https://ncbi.nlm.nih.gov/pubmed/23141927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.09.007
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