Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis

Pericytes have been identified as the major source of precursors of scar-producing myofibroblasts during kidney fibrosis. The underlying mechanisms triggering pericyte-myofibroblast transition are poorly understood. Transforming growth factor β-1 (TGF-β1) is well recognized as a pluripotent cytokine...

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Main Authors: Wu, Ching-Fang, Chiang, Wen-Chih, Lai, Chun-Fu, Chang, Fan-Chi, Chen, Yi-Ting, Chou, Yu-Hsiang, Wu, Ting-Hui, Linn, Geoffrey R., Ling, Hong, Wu, Kwan-Dun, Tsai, Tun-Jun, Chen, Yung-Ming, Duffield, Jeremy S., Lin, Shuei-Liong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2013
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538028/
https://ncbi.nlm.nih.gov/pubmed/23142380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.09.009
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