[18F]FLT and [18F]FDG PET for Non-invasive Treatment Monitoring of the Nicotinamide Phosphoribosyltransferase Inhibitor APO866 in Human Xenografts

INTRODUCTION: APO866 is a new anti-tumor compound inhibiting nicotinamide phosphoribosyltransferase (NAMPT). APO866 has an anti-tumor effect in several pre-clinical tumor models and is currently in several clinical phase II studies. 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) is a tracer used to ass...

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Auteurs principaux: Munk Jensen, Mette, Erichsen, Kamille Dumong, Johnbeck, Camilla Bardram, Björkling, Fredrik, Madsen, Jacob, Bzorek, Michael, Jensen, Peter Buhl, Højgaard, Liselotte, Sehested, Maxwell, Kjær, Andreas
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537726/
https://ncbi.nlm.nih.gov/pubmed/23308217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053410
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