Kif14 Mutation Causes Severe Brain Malformation and Hypomyelination

We describe a novel spontaneous mouse mutant, laggard (lag), characterized by a flat head, motor impairment and growth retardation. The mutation is inherited as an autosomal recessive trait, and lag/lag mice suffer from cerebellar ataxia and die before weaning. lag/lag mice exhibit a dramatic reduct...

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Главные авторы: Fujikura, Kohei, Setsu, Tomiyoshi, Tanigaki, Kenji, Abe, Takaya, Kiyonari, Hiroshi, Terashima, Toshio, Sakisaka, Toshiaki
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537622/
https://ncbi.nlm.nih.gov/pubmed/23308235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053490
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