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Kif14 Mutation Causes Severe Brain Malformation and Hypomyelination
We describe a novel spontaneous mouse mutant, laggard (lag), characterized by a flat head, motor impairment and growth retardation. The mutation is inherited as an autosomal recessive trait, and lag/lag mice suffer from cerebellar ataxia and die before weaning. lag/lag mice exhibit a dramatic reduct...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3537622/ https://ncbi.nlm.nih.gov/pubmed/23308235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053490 |
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