Unintegrated Lentivirus DNA Persistence and Accessibility to Expression in Nondividing Cells: Analysis with Class I Integrase Mutants

The circumstances under which unintegrated lentivirus DNA can persist and be a functional template for transcription and protein expression are not clear. We constructed and validated the first class I (nonpleiotropic) integrase (IN) mutants for a non-human lentivirus (feline immunodeficiency virus...

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Detalhes bibliográficos
Main Authors: Saenz, Dyana T., Loewen, Nils, Peretz, Mary, Whitwam, Todd, Barraza, Román, Howell, Kyle G., Holmes, Jonathan M., Good, Margaret, Poeschla, Eric M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC353756/
https://ncbi.nlm.nih.gov/pubmed/14990709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.6.2906-2920.2004
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