Repeated Low-Dose Mucosal Simian Immunodeficiency Virus SIVmac239 Challenge Results in the Same Viral and Immunological Kinetics as High-Dose Challenge: a Model for the Evaluation of Vaccine Efficacy in Nonhuman Primates

Simian immunodeficiency virus (SIV) challenge of rhesus macaques provides a relevant model for the assessment of human immunodeficiency virus (HIV) vaccine strategies. To ensure that all macaques become infected, the vaccinees and controls are exposed to large doses of pathogenic SIV. These nonphysi...

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Main Authors: McDermott, Adrian B., Mitchen, Jacque, Piaskowski, Shari, De Souza, Ivna, Yant, Levi J., Stephany, Jason, Furlott, Jessica, Watkins, David I.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC353751/
https://ncbi.nlm.nih.gov/pubmed/14990733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.6.3140-3144.2004
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