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Neurokinin-1 Receptor Directly Mediates Glioma Cell Migration by Up-regulation of Matrix Metalloproteinase-2 (MMP-2) and Membrane Type 1-Matrix Metalloproteinase (MT1-MMP)

Neurokinin-1 receptor (NK1R) occurs naturally on human glioblastomas. Its activation mediates glioma cell proliferation. However, it is unknown whether NK1R is directly involved in tumor cell migration. In this study, we found human hemokinin-1 (hHK-1), via NK1R, dose-dependently promoted the migrat...

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Bibliografske podrobnosti
Main Authors: Mou, Lingyun, Kang, Yawei, Zhou, Ying, Zeng, Qian, Song, Hongjing, Wang, Rui
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537028/
https://ncbi.nlm.nih.gov/pubmed/23166329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.389783
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