Properties of Cells Carrying the Herpes Simplex Virus Type 2 Thymidine Kinase Gene: Mechanisms of Reversion to a Thymidine Kinase-Negative Phenotype

We have isolated cells with a thymidine kinase-negative (tk(−)) phenotype from cells which carry the herpes simplex virus type 2 tk gene by selection in 5-bromodeoxyuridine or 9-(2-hydroxyethoxymethyl)guanine. Both selection routines generated revertants with a frequency of 10(−3) to 10(−4), and res...

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Bibliographic Details
Main Authors: Bastow, K. F., Darby, G., Wildy, P., Minson, A. C.
Format: Artigo
Language:Inglês
Published: 1980
Subjects:
Animal Viruses
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC353702/
https://ncbi.nlm.nih.gov/pubmed/16789205
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