Alteration of Introns in a Hyaluronan Synthase 1 (HAS1) Minigene Convert Pre-Mrna Splicing to the Aberrant Pattern in Multiple Myeloma (MM): MM Patients Harbor Similar Changes

Aberrant pre-mRNA splice variants of hyaluronan synthase 1 (HAS1) have been identified in malignant cells from cancer patients. Bioinformatic analysis suggests that intronic sequence changes can underlie aberrant splicing. Deletions and mutations were introduced into HAS1 minigene constructs to iden...

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Библиографические подробности
Главные авторы: Kriangkum, Jitra, Warkinton, Amanda, Belch, Andrew R., Pilarski, Linda M.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536762/
https://ncbi.nlm.nih.gov/pubmed/23301075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053469
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