Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?

ZD7288 has been widely used as a tool in the study of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels), and to test the relationships between HCN channels and heart and brain function. ZD7288 is widely considered a selective blocker of HCN currents. Here we show that ZD728...

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Autors principals: Wu, Xing, Liao, Liping, Liu, Xiangming, Luo, Fang, Yang, Tianming, Li, Chenhong
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2012
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Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536728/
https://ncbi.nlm.nih.gov/pubmed/22989944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.22209
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