Murine CD4(+)CD25(-) cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo

BACKGROUND: Induced regulatory T (iTreg) lymphocytes show promise for application in the treatment of allergic, autoimmune and inflammatory disorders. iTreg cells demonstrate advantages over natural Treg (nTreg) cells in terms of increased number of starting population and greater potential to proli...

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Bibliografiske detaljer
Main Authors: Majowicz, Anna, van der Marel, Sander, te Velde, Anje A, Meijer, Sybren L, Petry, Harald, van Deventer, Sander J, Ferreira, Valerie
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536706/
https://ncbi.nlm.nih.gov/pubmed/23198878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-230X-12-172
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