IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling

Although the transcription factors IRF-3 and IRF-7 are considered master regulators of type I interferon (IFN) induction and IFN stimulated gene (ISG) expression, Irf3(−/−)×Irf7(−/−) double knockout (DKO) myeloid dendritic cells (mDC) produce relatively normal levels of IFN-β after viral infection....

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Hlavní autoři: Lazear, Helen M., Lancaster, Alissa, Wilkins, Courtney, Suthar, Mehul S., Huang, Albert, Vick, Sarah C., Clepper, Lisa, Thackray, Larissa, Brassil, Margaret M., Virgin, Herbert W., Nikolich-Zugich, Janko, Moses, Ashlee V., Gale, Michael, Früh, Klaus, Diamond, Michael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536698/
https://ncbi.nlm.nih.gov/pubmed/23300459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003118
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