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WNK1/HSN2 Mutation in Human Peripheral Neuropathy Deregulates KCC2 Expression and Posterior Lateral Line Development in Zebrafish (Danio rerio)

Hereditary sensory and autonomic neuropathy type 2 (HSNAII) is a rare pathology characterized by an early onset of severe sensory loss (all modalities) in the distal limbs. It is due to autosomal recessive mutations confined to exon “HSN2” of the WNK1 (with-no-lysine protein kinase 1) serine-threoni...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bercier, Valérie, Brustein, Edna, Liao, Meijiang, Dion, Patrick A., Lafrenière, Ronald G., Rouleau, Guy A., Drapeau, Pierre
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536653/
https://ncbi.nlm.nih.gov/pubmed/23300475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003124
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