Transcriptional Profiling of Experimental CD8(+) Lymphocyte Depletion in Rhesus Macaques Infected with Simian Immunodeficiency Virus SIVmac239

CD8(+) T cells inhibit virus replication in SIV-infected rhesus macaques. However, it is unclear to what extent the viral suppression mediated by CD8(+) T cells reflects direct killing of infected cells as opposed to indirect, noncytolytic mechanisms. In this study, we used functional genomics to in...

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Hauptverfasser: Bosinger, Steven E., Jochems, Simon P., Folkner, Kathryn A., Hayes, Timothy L., Klatt, Nichole R., Silvestri, Guido
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Cellular Response to Infection
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536408/
https://ncbi.nlm.nih.gov/pubmed/23097439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01746-12
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