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Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism

Mutations in Parkin or PINK1 are the most common cause of recessive familial parkinsonism. Recent studies suggest that PINK1 and Parkin form a mitochondria quality control pathway that identifies dysfunctional mitochondria, isolates them from the mitochondrial network, and promotes their degradation...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Narendra, Derek, Walker, John E., Youle, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536340/
https://ncbi.nlm.nih.gov/pubmed/23125018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a011338
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