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Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism
Mutations in Parkin or PINK1 are the most common cause of recessive familial parkinsonism. Recent studies suggest that PINK1 and Parkin form a mitochondria quality control pathway that identifies dysfunctional mitochondria, isolates them from the mitochondrial network, and promotes their degradation...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3536340/ https://ncbi.nlm.nih.gov/pubmed/23125018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a011338 |
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