Neonatal Herpes Encephalitis Caused by a Virologically Confirmed Acyclovir-Resistant Herpes Simplex Virus 1 Strain

A neonate with herpes simplex virus 1 encephalitis was treated with intravenous acyclovir. During the course of therapy, the infection became intractable to the treatment and a mutation in the viral thymidine kinase gene (nucleotide G375T, amino acid Q125H) developed. This mutation was demonstrated...

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Autors principals: Kakiuchi, Satsuki, Nonoyama, Shigeaki, Wakamatsu, Hajime, Kogawa, Kazuhiro, Wang, Lixin, Kinoshita-Yamaguchi, Hitomi, Takayama-Ito, Mutsuyo, Lim, Chang-Kweng, Inoue, Naoki, Mizuguchi, Masashi, Igarashi, Takashi, Saijo, Masayuki
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Case Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536242/
https://ncbi.nlm.nih.gov/pubmed/23100343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.02247-12
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