Phosphoethanolamine Residues on the Lipid A Moiety of Neisseria gonorrhoeae Lipooligosaccharide Modulate Binding of Complement Inhibitors and Resistance to Complement Killing

Loss of phosphoethanolamine (PEA) from the lipid A of gonococcal strain FA19 results in increased sensitivity to killing by the classical pathway of complement. Here we demonstrate that loss of PEA from lipid A diminishes binding of the complement regulatory protein C4b binding protein (C4BP) to the...

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Autors principals: Lewis, Lisa A., Shafer, William M., Dutta Ray, Tathagat, Ram, Sanjay, Rice, Peter A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Host Response and Inflammation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536161/
https://ncbi.nlm.nih.gov/pubmed/23071134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00751-12
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