Use of Site-Directed Mutagenesis To Model the Effects of Spontaneous Deamidation on the Immunogenicity of Bacillus anthracis Protective Antigen

Long-term stability is a desired characteristic of vaccines, especially anthrax vaccines, which must be stockpiled for large-scale use in an emergency situation; however, spontaneous deamidation of purified vaccine antigens has the potential to adversely affect vaccine immunogenicity over time. In o...

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Main Authors: Verma, Anita, McNichol, Beth, Domínguez-Castillo, Rocío I., Amador-Molina, Juan C., Arciniega, Juan L., Reiter, Karine, Meade, Bruce D., Ngundi, Miriam M., Stibitz, Scott, Burns, Drusilla L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
Assuntos:
Microbial Immunity and Vaccines
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536148/
https://ncbi.nlm.nih.gov/pubmed/23115046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00863-12
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