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Network context and selection in the evolution to enzyme specificity
Enzymes are thought to have evolved highly specific catalytic activities from promiscuous ancestral proteins. By analyzing a genome-scale model of Escherichia coli metabolism, we found that 37% of its enzymes act on a variety of substrates and catalyze 65% of the known metabolic reactions. However,...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3536066/ https://ncbi.nlm.nih.gov/pubmed/22936779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1216861 |
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