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Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model
Recent advances in structural bioinformatics have enabled the prediction of protein-drug off-targets based on their ligand binding sites. Concurrent developments in systems biology allow for prediction of the functional effects of system perturbations using large-scale network models. Integration of...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2950675/ https://ncbi.nlm.nih.gov/pubmed/20957118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000938 |
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