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A Mutation of the RNA Polymerase β′ Subunit (rpoC) Confers Cephalosporin Resistance in Bacillus subtilis

In bacteria, mutations affecting the major catalytic subunits of RNA polymerase (encoded by rpoB and rpoC) emerge in response to a variety of selective pressures. Here we isolated a Bacillus subtilis strain with high-level resistance to cefuroxime (CEF). Whole-genome resequencing revealed only one m...

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Bibliografiske detaljer
Main Authors: Lee, Yong Heon, Nam, Ki Hyun, Helmann, John D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535988/
https://ncbi.nlm.nih.gov/pubmed/23070162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01449-12
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