Cytostatic versus Cytocidal Activities of Chloroquine Analogues and Inhibition of Hemozoin Crystal Growth

We report an improved, nonhazardous, high-throughput assay for in vitro quantification of antimalarial drug inhibition of β-hematin (hemozoin) crystallization performed under conditions that are more physiological relative to previous assays. The assay uses the differential detergent solubility of c...

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Autors principals: Gorka, Alexander P., Alumasa, John N., Sherlach, Katy S., Jacobs, Lauren M., Nickley, Katherine B., Brower, Jonathan P., de Dios, Angel C., Roepe, Paul D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535939/
https://ncbi.nlm.nih.gov/pubmed/23114783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01709-12
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