High β-Lactamase Levels Change the Pharmacodynamics of β-Lactam Antibiotics in Pseudomonas aeruginosa Biofilms

Resistance to β-lactam antibiotics is a frequent problem in Pseudomonas aeruginosa lung infection of cystic fibrosis (CF) patients. This resistance is mainly due to the hyperproduction of chromosomally encoded β-lactamase and biofilm formation. The purpose of this study was to investigate the role o...

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Bibliographic Details
Main Authors: Hengzhuang, Wang, Ciofu, Oana, Yang, Liang, Wu, Hong, Song, Zhijun, Oliver, Antonio, Høiby, Niels
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535908/
https://ncbi.nlm.nih.gov/pubmed/23089750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01393-12
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