Protection by a Recombinant Mycobacterium bovis Bacillus Calmette-Guérin Vaccine Expressing Shiga Toxin 2 B Subunit against Shiga Toxin-Producing Escherichia coli in Mice

We have developed a novel vaccine against Shiga toxin (Stx)-producing Escherichia coli (STEC) infection using a recombinant Mycobacterium bovis BCG (rBCG) system. Two intraperitoneal vaccinations with rBCG expressing the Stx2 B subunit (Stx2B) resulted in an increase of protective serum IgG and muco...

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Hlavní autoři: Fujii, Jun, Naito, Mariko, Yutsudo, Takashi, Matsumoto, Sohkichi, Heatherly, Daniel P., Yamada, Takeshi, Kobayashi, Hideyuki, Yoshida, Shin-ichi, Obrig, Tom
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535872/
https://ncbi.nlm.nih.gov/pubmed/23035176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00473-12
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