G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease

Polycystic kidney diseases are the most common genetic diseases that affect the kidney. There remains a paucity of information regarding mechanisms by which G proteins are regulated in the context of polycystic kidney disease to promote abnormal epithelial cell expansion and cystogenesis. In this st...

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Bibliographic Details
Main Authors: Kwon, Michelle, Pavlov, Tengis S., Nozu, Kandai, Rasmussen, Shauna A., Ilatovskaya, Daria V., Lerch-Gaggl, Alexandra, North, Lauren M., Kim, Hyunho, Qian, Feng, Sweeney, William E., Avner, Ellis D., Blumer, Joe B., Staruschenko, Alexander, Park, Frank
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535663/
https://ncbi.nlm.nih.gov/pubmed/23236168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216830110
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