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Complete Dependence on IRAK4 Kinase Activity in TLR2, but Not TLR4, Signaling Pathways Underlies Decreased Cytokine Production and Increased Susceptibility to Streptococcus pneumoniae Infection in IRAK4 Kinase-Inactive Mice
Interleukin-1 receptor-associated kinase 4 (IRAK4) is critical for MyD88-dependent Toll-like receptor (TLR) signaling, and patients with Irak4 mutations are extremely susceptible to recurrent bacterial infections. In these studies, mice homozygous for a mutant IRAK4 that lacks kinase activity (IRAK4...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535482/ https://ncbi.nlm.nih.gov/pubmed/23209321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201644 |
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