Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc

Despite the high prevalence of intervertebral disc disease, little is known about changes in intervertebral disc cells and their regenerative potential with ageing and intervertebral disc degeneration. Here we identify populations of progenitor cells that are Tie2 positive (Tie2(+)) and disialogangl...

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Main Authors: Sakai, Daisuke, Nakamura, Yoshihiko, Nakai, Tomoko, Mishima, Taishi, Kato, Shunichi, Grad, Sibylle, Alini, Mauro, Risbud, Makarand V., Chan, Danny, Cheah, Kathryn S.E., Yamamura, Ken-ichi, Masuda, Koichi, Okano, Hideyuki, Ando, Kiyoshi, Mochida, Joji
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535337/
https://ncbi.nlm.nih.gov/pubmed/23232394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2226
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