Supersaturated Self-Nanoemulsifying Drug Delivery Systems (Super-SNEDDS) Enhance the Bioavailability of the Poorly Water-Soluble Drug Simvastatin in Dogs

This study investigates the potential of supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) to improve the bioavailability of poorly water-soluble drugs compared to conventional SNEDDS. Conventional SNEDDS contained simvastatin (SIM) at 75% of the equilibrium solubility (S(eq))...

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Autori principali: Thomas, Nicky, Holm, René, Garmer, Mats, Karlsson, Jens Jakob, Müllertz, Anette, Rades, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2012
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535117/
https://ncbi.nlm.nih.gov/pubmed/23180162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9433-7
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