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Mechanism of Hyperphagia Contributing to Obesity in Brain-Derived Neurotrophic Factor Knockout Mice

Global-heterozygous and brain-specific homozygous knockouts (KO's) of brain-derived neurotrophic factor (BDNF) cause late- and early-onset obesity, respectively, both involving hyperphagia. Little is known about the mechanism underlying this hyperphagia or whether BDNF loss from peripheral tiss...

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Autori principali: Fox, Edward A., Biddinger, Jessica E., Jones, Kevin R., McAdams, Jennifer, Worman, Amber
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534937/
https://ncbi.nlm.nih.gov/pubmed/23069761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2012.09.078
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