Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors

The effect of the (R,S)-ketamine metabolites (R,S)-norketamine, (R,S)-dehydronorketamine, (2S,6S)-hydroxynorketamine and (2R,6R)- hydroxynorketamine on the activity of α7 and α3β4 neuronal nicotinic acetylcholine receptors was investigated using patch-clamp techniques. The data indicated that (R,S)-...

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Autors principals: Moaddel, Ruin, Abdrakhmanova, Galia, Kozak, Joanna, Jozwiak, Krzysztof, Toll, Lawrence, Jimenez, Lucita, Rosenberg, Avraham, Tran, Thao, Xiao, Yingxian, Zarate, Carlos A., Wainer, Irving W.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534778/
https://ncbi.nlm.nih.gov/pubmed/23183107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2012.11.023
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